| Manchester United – Tottenham |
10. Oct 16:30 |
| Atletico Madrid – Manchester United |
13. Oct 19:00 |
| Leeds – Manchester United |
18. Oct 13:00 |
| Como – Manchester United |
21. Oct 16:45 |
| Manchester United – Bournemouth |
25. Oct 14:00 |
| Chelsea – Manchester United |
31. Oct 12:30 |
| Manchester United – AS Roma |
03. Nov 20:00 |
| Manchester United – Aston Villa |
08. Nov 16:30 |
| Liverpool – Manchester United |
22. Nov 16:30 |
| Sporting CP – Manchester United |
25. Nov 20:00 |
| Manchester United – Brentford |
28. Nov 15:00 |
| Newcastle – Manchester United |
02. Dec 20:00 |
| Manchester United – Coventry |
05. Dec 15:00 |
| Manchester United – RB Leipzig |
08. Dec 20:00 |
| Crystal Palace – Manchester United |
12. Dec 15:00 |
| Arsenal – Manchester United |
19. Dec 15:00 |
| Manchester United – Nottingham Forest |
27. Dec 16:30 |
| Manchester United – Sunderland |
30. Dec 19:30 |
| Brighton – Manchester United |
02. Jan 12:30 |
| Manchester United – Newcastle |
07. Jan 20:00 |
| Aston Villa – Manchester United |
16. Jan 15:00 |
| Manchester United – Bayern München |
20. Jan 20:00 |
| Manchester United – Liverpool |
23. Jan 15:00 |
| Villarreal – Manchester United |
27. Jan 20:00 |
| Brentford – Manchester United |
30. Jan 15:00 |
| Manchester United – Chelsea |
06. Feb 15:00 |
| Manchester United – Brighton |
10. Feb 20:00 |
| Nottingham Forest – Manchester United |
20. Feb 15:00 |
| Manchester United – Arsenal |
27. Feb 15:00 |
| Sunderland – Manchester United |
03. Mar 20:00 |
| Manchester United – Everton |
13. Mar 15:00 |
| Manchester City – Manchester United |
20. Mar 15:00 |
| Manchester United – Hull City |
10. Apr 14:00 |
| Ipswich – Manchester United |
17. Apr 14:00 |
| Manchester United – Crystal Palace |
24. Apr 14:00 |
| Coventry – Manchester United |
01. May 14:00 |
| Bournemouth – Manchester United |
08. May 14:00 |
| Manchester United – Leeds |
15. May 14:00 |
| Tottenham – Manchester United |
23. May 14:00 |
| Manchester United – Fulham |
30. May 15:00 |
